The long noncoding RNA MALAT1 predicts human islet isolation quality
نویسندگان
چکیده
منابع مشابه
Induction of long noncoding RNA MALAT1 in hypoxic mice
Long thought to be "junk DNA", in recent years it has become clear that a substantial fraction of intergenic genomic DNA is actually transcribed, forming long noncoding RNA (lncRNA). Like mRNA, lncRNA can also be spliced, capped, and polyadenylated, affecting a multitude of biological processes. While the molecular mechanisms underlying the function of lncRNAs have just begun to be elucidated, ...
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Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a cancer-promoting long noncoding RNA, accumulates in cells by using a 3'-triple-helical RNA stability element for nuclear expression (ENE). The ENE, a stem-loop structure containing a U-rich internal loop, interacts with a downstream A-rich tract (ENE+A) to form a blunt-ended triple helix composed of nine U•A-U triples interrupte...
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Myostatin, a member of the transforming growth factor-β (TGF-β) superfamily of secreted proteins, is a potent negative regulator of myogenesis. Free myostatin induces the phosphorylation of the Smad family of transcription factors, which, in turn, regulates gene expression, via the canonical TGF-β signaling pathway. There is, however, emerging evidence that myostatin can regulate gene expressio...
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Neuroblastoma is the most common solid tumor during early childhood. One of the key features of neuroblastoma is extensive tumor-driven angiogenesis due to hypoxia. However, the mechanism through which neuroblastoma cells drive angiogenesis is poorly understood. Here we show that the long noncoding RNA MALAT1 was upregulated in human neuroblastoma cell lines under hypoxic conditions. Conditione...
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1Institute of Cardiovascular Regeneration, University Frankfurt, Frankfurt, Germany; 2Max-DelbrückCentrum für Molekulare Medizin (MDC), Berlin-Buch, Germany; 3GeorgSpeyer-Haus, Institute for Tumor Biology and Experimental Tumor Therapy, Frankfurt, Germany; 4Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany, and; 5German Center for Cardiovascular Research (DZHK), Partner sit...
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ژورنال
عنوان ژورنال: JCI Insight
سال: 2019
ISSN: 2379-3708
DOI: 10.1172/jci.insight.129299